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The Pathophysiology of Pain: Focus on Central Sensitization
Pain is a complex biopsychosocial
process often involving the peripheral
nervous system (PNS) and
always involving the central nervous
system (CNS). For example, tissue injury
may activate the PNS, which may transmit
nociceptive signals through the spinal
cord to the brain, where pain perception
occurs. In other instances, such as in central
post-stroke pain, the role of the PNS
is minimized.
AUGUST, 2008 |
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A Mechanistic Approach to the Management of Neuropathic Pain
Linking Pathophysiology, Diagnosis, and Treatment
Neuropathic pain is the clinical consequence
of disruption of the normal physiology
of a neuron or neural network. In
recent years, expanded insight into the
pathophysiology of neuropathic pain has
led to a paradigm shift in classification,
with a new basis on mechanism rather
than etiology or anatomic localization.
MAY, 2008 |
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Long-Acting Opioids in the Treatment of Chronic Non–Cancer-Related Pain Conditions
In America, 75 million people experience
chronic pain, which the International
Association for the Study of Pain (IASP)
defines as pain without apparent biological
value continuing beyond the normal tissue
healing time (3 months). Chronic pain
erodes physical, psychological, and social
well-being, and patients frequently experience
sleep disturbance, depression, and
anxiety.
JANUARY, 2008 |
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Managing Cancer-Related Breakthrough Pain With FENTORA
Breakthrough pain (BTP) in patients with cancer is a common, distressing and costly problem. It interferes with functional capacities and virtually all quality-of-life measures, and adds appreciably to physical and psychological morbidity.
OCTOBER, 2007 |
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New Pharmacologic Treatment Options for Chronic/Persistent Pain
Chronic pain, sometimes referred to as
persistent pain, is defined as pain that continues
beyond the time normally associated
with healing for a specific illness or initial
injury. Chronic pain has been estimated to
affect 57% of Americans, and 3 out of 5 people
affected have lived with chronic pain for
more than 1 year.
AUGUST, 2007 |
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Case Challenges in Pain Management:
Opioid Therapy for Chronic Pain
An estimated 50 to 60 million people in the United States suffer from
chronic pain resulting from injury, bone and joint diseases, diabetes, infection,
malignancy, and other conditions. Patients with uncontrolled chronic pain
often are unable to meet the demands of their personal and professional lives;
not surprisingly, chronic pain has been estimated to cost U.S. employers at
least $61.2 billion per year in lost productivity, while expenditures on pain
treatments may be as much as $1.5 billion globally.
APRIL, 2007 |
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Neuroimaging of Pain
Pain is a major healthcare problem in the
United States, where an estimated 50
million people suffer from chronic discomfort
that is linked to $200 billion in
direct and indirect medical resources
annually. The importance of pain as a
major worldwide healthcare problem has
been recognized by the World Health
Organization,1 and the need for further
research into the mechanisms and control
of pain was recognized by the US
Congress in its declaration of the years
2001 to 2010 as the Decade of Pain
Control and Research.
APRIL, 2007 |
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